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October 8, 2025BMC Oral HealthOpen Access

Salivary chromogranin a levels in periodontal health status: a cross-sectional study evaluating clinical and psychological associations

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Authors

FSFatma SoysalSİSıla Çağrı İşlerZGZeliha Güney

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Overview

Cross-sectional study evaluates salivary chromogranin A in periodontal disease, suggesting stress-related immune responses.

Key Points

  • Salivary chromogranin A levels were significantly higher in Stage III periodontitis compared to periodontal health.
  • In participants with advanced periodontal disease, no significant correlation was found between chromogranin A levels and psychological stress measures.
  • Clinical periodontal parameters were assessed alongside psychological stress using the Beck Depression Inventory.
  • Findings indicate chromogranin A may reflect systemic stress-related immune changes linked to disease severity.

Cite This Study

Soysal et al. (2025) studied this question.

synapsesocial.com/papers/68e6679587ecc93a24d17442https://doi.org/10.1186/s12903-025-06912-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of Salivary Stress Biomarkers in Patients with and without Periodontal Diseases: A Cross-sectional Study.2026
  2. 2Evaluating the Clinico-biochemical Association between Stress and Chronic Periodontitis by Estimation of Serum Cortisol and Serum Chromogranin A Levels2024 · 8 citations
  3. 3Salivary Cortisol and Periodontitis Severity: A Cross-Sectional Biomarker-Based Assessment of Stress and Inflammation2025
  4. 4Salivary chromogranin a reflects autonomic regulation during “wake to sleep” and “sleep to wake” transitions2025
  5. 5Quantification of Salivary Chromogranin A Levels during Routine Dental Procedures in Children: An In Vivo Study2024