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September 24, 2025Frontiers in ImmunologyOpen Access

Association of salivary lactoferrin, Porphyromoras gingivalis and stress hormone levels in patients with periodontitis: a pilot study

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Authors

DADesireé AntequeraEBElena BuetasSGSandra García‐Esteban

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Overview

Pilot study shows higher levels of lactoferrin and stress hormones in patients with periodontitis, implying possible links to immune pathways.

Key Points

  • Patients with periodontitis had significantly elevated salivary lactoferrin, cortisol, and DHEA levels compared to controls, indicating immune response.
  • Strong correlations between P. gingivalis levels and salivary markers were found, suggesting a link between oral bacteria and stress responses.
  • Salivary and subgingival P. gingivalis positively correlated with clinical parameters like BoP and PPD, indicating disease severity.
  • Findings support the notion that immune and hormonal dysregulation may impact systemic diseases, including neurodegenerative conditions.

Cite This Study

Antequera et al. (2025) studied this question.

synapsesocial.com/papers/68d6d8978b2b6861e4c3ee56https://doi.org/10.3389/fimmu.2025.1681095
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Porphyromonas gingivalis in Alzheimer’s disease: Association with salivary lactoferrin and inflammatory response2026 · 1 citations
  2. 2Salivary Cortisol and Periodontitis Severity: A Cross-Sectional Biomarker-Based Assessment of Stress and Inflammation2025 · 4 citations
  3. 3Association between the concentration of salivary lactoferrin, smoking, and periodontal disease parameters: A randomized observational study2024
  4. 4Comparison of Salivary Stress Biomarkers in Patients with and without Periodontal Diseases: A Cross-sectional Study.2026
  5. 5Effect of Psychological Stress on Malondialdehyde Levels in the Saliva of Postmenopausal Women With Chronic Periodontitis”2024