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September 10, 2025Journal of international oral health

Impact of Stress on Periodontitis Severity: A Clinical and Molecular Cross-Sectional Analysis

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Authors

SVSmrithi Vishakha VarmaSVSheeja VargheseSNS. Narasimhan

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Overview

Cross-sectional analysis shows chronic stress raises inflammatory biomarkers in periodontitis, suggesting implications for treatment.

Key Points

  • Higher perceived stress correlates with elevated inflammatory biomarkers like IL-1β and cortisol, revealing stress's impact on systemic inflammation.
  • Despite increased biomarkers, no significant association with clinical attachment loss was detected, with CAL linked more to age and serum VIP levels.
  • Conducted as a cross-sectional observational study involving 80 participants from a dental outpatient setting to explore relationships effectively.
  • Findings highlight the complexity of periodontitis progression, suggesting stress management may improve treatment outcomes.

Cite This Study

Varma et al. (2025) studied this question.

synapsesocial.com/papers/68c1d97154b1d3bfb60faae3https://doi.org/10.4103/jioh.jioh_142_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Salivary Cortisol and Periodontitis Severity: A Cross-Sectional Biomarker-Based Assessment of Stress and Inflammation2025 · 4 citations
  2. 2The interplay between stress and periodontal health: A systematic review2025
  3. 3Periodontal Health and Its Relationship with Psychological Stress: A Cross-Sectional Study2024 · 25 citations
  4. 4Evaluation of Stress and Salivary Neuropeptides in Periodontal Health and Disease2026
  5. 5Analyzing the Relationship Between Chronic Periodontitis and Psychological Stress in Elderly Patients: A Study Protocol2024