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September 10, 2025Medical SciencesOpen Access

Salivary Cortisol and Periodontitis Severity: A Cross-Sectional Biomarker-Based Assessment of Stress and Inflammation

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Authors

VDVelitchka Dosseva-PanovaMedical University of SofiaAMAntoaneta MlachkovaMedical University of SofiaMMMarina MitevaMedical University of Sofia

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Overview

Cross-sectional assessment reveals salivary cortisol correlates with periodontitis severity and inflammation.

Key Points

  • Salivary cortisol levels were significantly higher in patients with Stage III/IV periodontitis compared to Stage I/II.
  • Patients with Grade C periodontitis exhibited higher salivary cortisol than those with Grade B, indicating potential stress associations.
  • Cortisol was identified as an independent predictor for both Stage III/IV and Grade C periodontitis in multivariate analysis.
  • Correlation analysis showed significant links between cortisol levels, clinical disease markers, and inflammatory cytokines IL-1β and IL-6.

Cite This Study

Dosseva-Panova et al. (2025) studied this question.

synapsesocial.com/papers/68c1c62654b1d3bfb60f174ehttps://doi.org/10.3390/medsci13030120
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of Stress on Periodontitis Severity: A Clinical and Molecular Cross-Sectional Analysis2025
  2. 2Comparison of Salivary Stress Biomarkers in Patients with and without Periodontal Diseases: A Cross-sectional Study.2026
  3. 3Evaluating the Clinico-biochemical Association between Stress and Chronic Periodontitis by Estimation of Serum Cortisol and Serum Chromogranin A Levels2024 · 8 citations
  4. 4Evaluation of Stress and Salivary Neuropeptides in Periodontal Health and Disease2026
  5. 5Salivary IL-1β, IL-6, and IL-10 Are Key Biomarkers of Periodontitis Severity2024 · 19 citations