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June 26, 2026

Comparison of Salivary Stress Biomarkers in Patients with and without Periodontal Diseases: A Cross-sectional Study.

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Authors

RJRana Hameed JabrOAOmar Husham Ali

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Overview

Cross-sectional study evaluates salivary biomarkers in individuals with periodontal disease, indicating stress levels.

Key Points

  • This study evaluates salivary biomarkers in periodontally healthy individuals and those with periodontal diseases to assess psychological stress levels.
  • Cross-sectional study involving 400 participants aged ≥18 years, including 117 healthy participants and 263 with periodontal disease.
  • Salivary samples were collected from 90 systematically randomized participants and analyzed for biomarkers using the ELISA test.
  • Psychological stress was assessed using the Perceived Stress Scale (PSS) alongside periodontal examination.
  • Salivary cortisol levels were significantly higher in gingivitis (65.89 ng/ml) and periodontitis (47.06 ng/ml) compared to controls (33.54 ng/ml).
  • Mean CgA levels were elevated in gingivitis (1133.47 pg/ml) and periodontitis (1526.30 pg/ml) compared to controls (724.75 pg/ml).
  • Higher sAA levels were observed in gingivitis (31.44 ng/ml) and periodontitis (34.13 ng/ml) versus controls (24.40 ng/ml).

Cite This Study

Jabr et al. (2026) studied this question.

synapsesocial.com/papers/6a3e176b030ad1a9b3090dfdhttps://doi.org/10.3290/j.ohpd.c_2741
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Salivary chromogranin a levels in periodontal health status: a cross-sectional study evaluating clinical and psychological associations2025 · 1 citations
  2. 2Salivary Cortisol and Periodontitis Severity: A Cross-Sectional Biomarker-Based Assessment of Stress and Inflammation2025
  3. 3Evaluating the Clinico-biochemical Association between Stress and Chronic Periodontitis by Estimation of Serum Cortisol and Serum Chromogranin A Levels2024 · 8 citations
  4. 4Evaluation of Stress and Salivary Neuropeptides in Periodontal Health and Disease2026
  5. 5Association of salivary lactoferrin, Porphyromoras gingivalis and stress hormone levels in patients with periodontitis: a pilot study2025 · 7 citations