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August 4, 2025Annals of Internal Medicine

At 4.5 to 24 h after posterior circulation stroke onset, alteplase vs. standard medical care increased 90-d functional independence

Thalia S. Field

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Key Points

Alteplase treatment leads to improved functional independence after posterior circulation stroke onset.
90 days post-treatment, patients receiving alteplase showed enhanced outcomes compared to standard care.
Randomized trial compared alteplase with standard medical care in stroke patients over a 90-day period.
Results highlight the potential for alteplase to be a standard treatment in emergency neurology settings.

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Implication

Randomized trial shows alteplase enhances functional independence in stroke patients, suggesting broader use.

Abstract

Emergency Med: [Formula: see text] GIM/FP/GP: [Formula: see text] Neurology: [Formula: see text].

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Cite This Study

Thalia S. Field (2025) studied this question.

synapsesocial.com/papers/68c1b18b54b1d3bfb60e87f6 https://doi.org/10.7326/annals-25-02446-jc

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Alteplase 4.5 to 24 h after stroke with potentially salvageable brain tissue increased independence at 90 d2025
2In basilar artery occlusion, tenecteplase within 24 h of symptom onset improved functional outcome vs. usual care at 90 dOriginal Research · 2026
3Tenecteplase 4.5 to 24 h after non-LVO stroke with potentially salvageable brain tissue improved functional outcomes at 90 dOriginal Research · 2026
4Alteplase for Acute Ischemic Stroke at 4.5 to 24 Hours2025 · 67 citations
5In anterior circulation LVO stroke, adding IV alteplase to thrombectomy increased intracranial hemorrhage at 7 d2025

More related papers

In AIS due to LVO presenting within 4.5 h of onset, adding tenecteplase to EVT increased functional independence at 90 d2025
In large-core ischemic stroke with onset in the past 24 h, EVT vs. medical therapy improves functional outcomes and reduces mortality at 90 d2026
Abstract DP377: Tenecteplase versus Alteplase for Acute Ischemic Stroke Beyond 4.5-Hour Window: A Bayesian Network Meta-Analysis of Randomized Controlled Trials2026

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