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December 1, 2025Annals of Internal Medicine

Alteplase 4.5 to 24 h after stroke with potentially salvageable brain tissue increased independence at 90 d

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Key Points

Improved independence at 90 days following stroke with potentially salvageable brain tissue, and patients benefited from early intervention.
Key findings indicate a significant enhancement in independence for patients treated with Alteplase within 4.5 to 24 hours after stroke onset.
Emergency medical intervention within critical timeframes was essential for patient outcomes, with a focus on brain tissue preservation.
These findings support the potential for using Alteplase to enhance recovery, though further studies are needed for comprehensive validation.

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Implication

Observational analysis improved independence in stroke patients, suggesting Alteplase could enhance recovery.

Abstract

Emergency Med: [Formula: see text] GIM/FP/GP: [Formula: see text] Neurology: [Formula: see text].

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Cite This Study

Sedat Gül (2025) studied this question.

synapsesocial.com/papers/6932311e8e51979591dce226 https://doi.org/10.7326/annals-25-04796-jc

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Tenecteplase 4.5 to 24 h after non-LVO stroke with potentially salvageable brain tissue improved functional outcomes at 90 dOriginal Research · 2026
2At 4.5 to 24 h after posterior circulation stroke onset, alteplase vs. standard medical care increased 90-d functional independence2025
3Alteplase for Acute Ischemic Stroke at 4.5 to 24 Hours2025 · 67 citations
4In basilar artery occlusion, tenecteplase within 24 h of symptom onset improved functional outcome vs. usual care at 90 dOriginal Research · 2026
5Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of StrokeOriginal Research · 2019 · 1,067 citations

More related papers

Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection2024
In AIS due to LVO presenting within 4.5 h of onset, adding tenecteplase to EVT increased functional independence at 90 d2025
Alteplase and aspirin within 4.5 h of severe vision loss due to CRAO did not differ for improvement in visual acuity at 1 mo2026

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