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February 2, 2026Annals of Internal Medicine

Alteplase and aspirin within 4.5 h of severe vision loss due to CRAO did not differ for improvement in visual acuity at 1 mo

Christopher R. Carpenter

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Key Points

To investigate the effects of alteplase and aspirin on visual acuity improvement in cases of central retinal artery occlusion (CRAO).
Administered alteplase or aspirin within 4.5 hours of severe vision loss
Compared visual acuity outcomes after one month
Used a controlled emergency medicine approach
No significant differences in visual acuity improvement between the two treatments
Both alteplase and aspirin showed limited efficacy in improving vision in CRAO patients
Results highlight the need for further investigation into effective treatments for CRAO

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Implication

Emergency medicine observations reveal no difference in visual acuity improvement with alteplase or aspirin in CRAO cases.

Abstract

Emergency Med: [Formula: see text] Neurology: [Formula: see text].

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Cite This Study

Christopher R. Carpenter (2026) studied this question.

synapsesocial.com/papers/6984345ff1d9ada3c1fb2790 https://doi.org/10.7326/annals-25-05284-jc

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Alteplase 4.5 to 24 h after stroke with potentially salvageable brain tissue increased independence at 90 d2025
2In basilar artery occlusion, tenecteplase within 24 h of symptom onset improved functional outcome vs. usual care at 90 dOriginal Research · 2026
3Tenecteplase 4.5 to 24 h after non-LVO stroke with potentially salvageable brain tissue improved functional outcomes at 90 dOriginal Research · 2026
4Abstract WP059: Effectiveness of low-dose intravenous alteplase in acute central retinal artery occlusionRCT · 2026
5At 4.5 to 24 h after posterior circulation stroke onset, alteplase vs. standard medical care increased 90-d functional independence2025

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Tenecteplase in Central Retinal Artery Occlusion Study (TenCRAOS): Protocol for a randomized-controlled trial2025
Intravenous Thrombolysis for Acute Central Retinal Artery Occlusion: Protocol For a Systematic Review and Individual Participant Data Meta-Analysis of Randomized Controlled Trials2025
Updates in Central Retinal Artery Occlusion2026

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