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December 1, 2025Annals of Internal Medicine

In anterior circulation LVO stroke, adding IV alteplase to thrombectomy increased intracranial hemorrhage at 7 d

Sedat Gül Ken Uchino

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Key Points

Increased intracranial hemorrhage occurs following the addition of IV alteplase, impacting patient safety.
The study focused on patients with anterior circulation large vessel occlusion stroke at day 7 post-treatment.
Analysis of clinical outcomes from combining IV alteplase and thrombectomy in stroke management highlights potential risks.
This data on thrombolytics and surgical interventions calls for caution in clinical settings.

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Implication

Observational analysis increased intracranial hemorrhage in patients undergoing thrombectomy and IV alteplase, indicating safety concerns.

Abstract

GIM/FP/GP: [Formula: see text] Neurology: [Formula: see text].

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Cite This Study

Gül et al. (2025) studied this question.

synapsesocial.com/papers/6932311e8e51979591dce223 https://doi.org/10.7326/annals-25-04797-jc

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Stroke Etiologies With Intravenous Thrombolysis before Thrombectomy and Functional Outcomes in Anterior Circulation Large Vessel OcclusionOriginal Research · 2026 · 1 citations
2In AIS due to LVO presenting within 4.5 h of onset, adding tenecteplase to EVT increased functional independence at 90 d2025
3Alteplase 4.5 to 24 h after stroke with potentially salvageable brain tissue increased independence at 90 d2025
4In acute ischemic stroke with large core infarct, EVT improves mRS scores but increases symptomatic intracranial hemorrhage at 90 d2025
5Intra-Arterial Alteplase After Successful Endovascular Reperfusion in Acute StrokeRCT · 2025 · 26 citations

More related papers

Second-dose intravenous thrombolysis with tenecteplase in alteplase-resistant medium-vessel-occlusion strokes: A retrospective and comparative study2024
<scp>IV</scp> Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke2026
IV Thrombolysis Before Thrombectomy in Carotid Artery Dissection-Related Large-Vessel Occlusion.2026

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