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September 10, 2025Journal of Physics G Nuclear and Particle Physics

47Sc production for medical applications: cross-section optimization with genetic algorithms

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Authors

YLYu. A. LashkoLCL. CantonLZL. Zangrando

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Overview

Optimization improves radionuclidic purity and yield in scandium-47 production, suggesting clinical limitations.

Key Points

  • Genetic algorithm optimization enhances model accuracy for scandium-47 yields.
  • Results show default TALYS predictions overestimate yields of scandium-47 and scandium-48.
  • Proton irradiation of enriched titanium-49 was modeled using TALYS nuclear reaction code.
  • The study highlights potential issues with radionuclidic purity for clinical applications.

Cite This Study

Lashko et al. (2025) studied this question.

synapsesocial.com/papers/68c1b18b54b1d3bfb60e8919https://doi.org/10.1088/1361-6471/adf766
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Proton-induced reactions for 47Sc (and 46Sc) production: new nuclear cross section measurements on enriched titanium targets2024 · 2 citations
  2. 2Energy dependent production and radionuclidic purity of $$\:{\:}^{47}\mathbf{S}\mathbf{c}\:$$from $$\:{\:}^{48}\mathbf{C}\mathbf{a}(\varvec{p},\varvec{x}\varvec{n})\:$$reactions: a combined theoretical and data from EXFOR library using the EMPIRE code2026
  3. 3Investigation of 44ti (N, P) and44 Ti (D, 2p) Reactions in the Production of 44sc for Theranostic Applications2025
  4. 4Experimental evaluation of 47Sc production by neutron irradiation of metallic titanium at the IEA-R1 research reactor2026
  5. 5Endorsing Titanium–Scandium Radionuclide Generator for PET and Positronium Imaging2026