What does this research mean for the field?

Efficient production of the long-lived parent isotope 44Ti is achievable using proton beams in the 20–30 MeV range, enabling a practical titanium–scandium radionuclide generator for routine and decentralized supply of 44Sc for PET imaging. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate and optimize production pathways for titanium-44 to establish a decentralized titanium-scandium radionuclide generator for PET and positronium imaging.

January 19, 2026Acta Physica Polonica AOpen Access

Endorsing Titanium–Scandium Radionuclide Generator for PET and Positronium Imaging

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Authors

PMP. Moskal AKA. Khreptak JCJ. Choiński

Discussion

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Overview

Nuclear reaction analysis demonstrates feasible titanium-44 production via 20–30 MeV proton beams, indicating a scalable pathway for decentralized scandium-44 medical imaging.

Key Points

To evaluate and optimize production pathways for titanium-44 to establish a decentralized titanium-scandium radionuclide generator for PET and positronium imaging.
Analyzed nuclear reaction pathways, including proton and deuteron reactions on scandium targets, as well as alpha-particle and lithium-induced reactions on calcium.
Assessed optimal beam energy parameters, target designs, expected production yields, and compatibility with existing cyclotron facilities.
Identified proton beam irradiation on scandium targets within the 20–30 MeV range under extended irradiation as the most efficient route for titanium-44 synthesis.
Demonstrated that parent titanium-44 (half-life of 59.1 years) provides a sustainable platform to elute pure scandium-44 on demand for decentralized clinical use.

Cite This Study

Moskal et al. (2026) studied this question.

synapsesocial.com/papers/6a1ff710d47ed904550da988 https://doi.org/10.12693/aphyspola.148.s152

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January 19, 2026Acta Physica Polonica AOpen Access

Endorsing Titanium–Scandium Radionuclide Generator for PET and Positronium Imaging

View Full Paper

Ask AI

Bookmark

Authors

PMP. Moskal AKA. Khreptak JCJ. Choiński

Discussion

Member takes

Overview

Nuclear reaction analysis demonstrates feasible titanium-44 production via 20–30 MeV proton beams, indicating a scalable pathway for decentralized scandium-44 medical imaging.

Key Points

To evaluate and optimize production pathways for titanium-44 to establish a decentralized titanium-scandium radionuclide generator for PET and positronium imaging.
Analyzed nuclear reaction pathways, including proton and deuteron reactions on scandium targets, as well as alpha-particle and lithium-induced reactions on calcium.
Assessed optimal beam energy parameters, target designs, expected production yields, and compatibility with existing cyclotron facilities.
Identified proton beam irradiation on scandium targets within the 20–30 MeV range under extended irradiation as the most efficient route for titanium-44 synthesis.
Demonstrated that parent titanium-44 (half-life of 59.1 years) provides a sustainable platform to elute pure scandium-44 on demand for decentralized clinical use.

Cite This Study

Moskal et al. (2026) studied this question.

synapsesocial.com/papers/6a1ff710d47ed904550da988 https://doi.org/10.12693/aphyspola.148.s152

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