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September 10, 2025Chemistry LettersOpen Access

Ala-[1-13C]Gly-d2-15NMe2: Hyperpolarized Molecular Probe for Aminopeptidase N Activity with Suppressed Scalar Relaxation

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Ala-[1-13C]Gly-d2-15NMe2 improves MR signal intensity for aminpeptidase n activity, enabling better detection.
Enhanced MR signal intensity was achieved without requiring careful sample handling, making the probe versatile.
This development pertains to nuclear magnetic resonance imaging techniques that leverage dynamic nuclear polarization.
The probe has significant potential for cellular studies in complex organisms, simplifying pre-injection procedures.

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A novel molecular probe improves MR signal intensity in enzymatic activity detection, highlighting applications in disease models.

Saito et al. (2025) studied this question.

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