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September 10, 2025Journal of Clinical MedicineOpen Access

Mapping the Mind: Gray Matter Signatures of Personality Pathology in Female Adolescent Anorexia Nervosa Persist Through Treatment

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Authors

LLLukas LenhartMGManuela GanderRSRuth Steiger

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Overview

Analysis shows gray matter alterations in personality disorders in adolescents with anorexia nervosa, suggesting implications for treatment approaches.

Key Points

  • Significant positive associations were found between personality disorder scores and gray matter volume in specific brain regions, indicating a link.
  • Imaging revealed that volume changes in the mid-cingulate cortex related to personality disorders persisted even after treatment in adolescents with anorexia nervosa.
  • The study utilized magnetic resonance imaging and voxel-based morphometry to analyze structural brain changes before and after treatment for anorexia.
  • Findings highlight the potential need for tailored therapeutic approaches in managing personality disorders along with anorexia nervosa.

Cite This Study

Lenhart et al. (2025) studied this question.

synapsesocial.com/papers/68c1b34d54b1d3bfb60e99d2https://doi.org/10.3390/jcm14155438
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Also Consider

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  1. 1Clinical heterogeneity of feeding and eating disorders: using personality psychopathology to differentiate “simplex” and “complex” phenotypes2024 · 4 citations
  2. 2Inpatient adolescents with borderline personality disorder features: Identity diffusion and narrative incoherence.2019 · 68 citations
  3. 3Attachment Trauma Is Associated with White Matter Fiber Microstructural Alterations in Adolescents with Anorexia Nervosa before and after Exposure to Psychotherapeutic and Nutritional Treatment2023 · 4 citations