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June 11, 2026Open Access

Grey matter volume associations with personality functioning in a clinical cohort of female youths

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Authors

MTMadelyn ThomsonMCMarialuisa CaveltiIMInes Mürner‐Lavanchy

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Overview

Randomized trial investigates grey matter volume associations with personality functioning in female youths, suggesting no significant findings.

Key Points

  • The study aimed to examine the relationship between grey matter volume and dimensional personality functioning in female youths with varying borderline personality disorder pathology.
  • N = 93 females (ages 14–21) assessed using structural MRI and the STiP-5.1 interview.
  • Participants included full-threshold BPD, sub-threshold BPD, and healthy controls, reflecting dimensional personality pathology.
  • Multiple linear regression analyses evaluated associations between STiP-5.1 scores and grey matter volume.
  • No significant association found between STiP-5.1 total score and total grey matter volume (p = 0.61).
  • Individual brain regions and STiP-5.1 total score showed non-significant results (all corrected p values ≥0.82).
  • Validity checks using BPD criteria confirmed STiP-5.1 findings, with no evidence linking personality functioning to grey matter volume in young females.

Cite This Study

Thomson et al. (2026) studied this question.

synapsesocial.com/papers/6a2a526080c8f91e7f39e66ehttps://doi.org/10.48620/96605
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Grey matter volume associations with personality functioning in a clinical cohort of female youths2026
  2. 2Mapping the Mind: Gray Matter Signatures of Personality Pathology in Female Adolescent Anorexia Nervosa Persist Through Treatment2025
  3. 3Assessment of neurotransmitter-related structural brain changes in borderline personality disorder: an MRI study2026
  4. 4Neuroimaging insights into Borderline Personality Disorder patients with and without suicide attempts: A multi-modal structural MRI study.2026
  5. 5Personality functioning as a dimensional context for mentalization and neurocognition in borderline personality disorder2026