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June 6, 2026Scientific ReportsOpen Access

Assessment of neurotransmitter-related structural brain changes in borderline personality disorder: an MRI study

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Authors

MPMichela PievaniEGElena GattiVBValeria Bracca

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Overview

Exploratory study reveals grey matter changes in BPD, but no link to neurotransmitter systems.

Key Points

  • This study explores the relationship between grey matter alterations and neurotransmitter systems in individuals with borderline personality disorder.
  • Assessed grey matter volume using 3T MRI and voxel-based morphometry in 58 BPD patients and 28 healthy controls.
  • Compared GM volumes between BPD patients and healthy controls across various brain regions.
  • Analyzed correlations between GM volume differences and neurotransmitter distribution maps.
  • Observed smaller grey matter volumes in BPD patients in limbic, temporo-parietal, frontal medial, olfactory, and cerebellar regions (p FDR <0.05).
  • No significant association between GM abnormalities and neurotransmitter systems (p FDR >0.05).
  • Results do not support a direct relationship between structural brain changes and major neurotransmitter systems in BPD.

Cite This Study

Pievani et al. (2026) studied this question.

synapsesocial.com/papers/6a23b91b71a5da9775e75186https://doi.org/10.1038/s41598-026-56165-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neuroimaging insights into Borderline Personality Disorder patients with and without suicide attempts: A multi-modal structural MRI study.2026
  2. 2Grey matter volume associations with personality functioning in a clinical cohort of female youths2026
  3. 3Understanding the Borderline Brain: A Review of Neurobiological Findings in Borderline Personality Disorder (BPD)2025 · 15 citations
  4. 4Grey matter volume associations with personality functioning in a clinical cohort of female youths2026
  5. 5Neural Correlates of Borderline Personality Disorder (BPD) Based on Electroencephalogram (EEG)—A Mechanistic Review2025 · 5 citations