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September 10, 2025Ultrasound in Medicine & BiologyOpen Access

Real-time Imaging of Vascular Changes and Extravasation in the Chicken Chorioallantoic Membrane (CAM) Model Exposed to Ultrasound and Microbubbles

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Authors

MMMelina MühlenpfordtENEllen Helgeland NymarkAÅAndreas Åslund

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Overview

Study demonstrates vascular changes and extravasation in the chicken chorioallantoic membrane model, indicating ultrasound and microbubbles may enhance drug delivery.

Key Points

  • Ultrasound exposure combined with microbubbles improved drug delivery in the chicken chorioallantoic membrane model.
  • Extravasation of fluorescein isothiocyanate-dextran exhibited both rapid and slow kinetics under ultrasound treatment and microbubble activation.
  • Acoustic cluster therapy using large microbubbles showed significant vascular effects, including changes in blood flow direction and occlusion.
  • The chicken chorioallantoic membrane model is effective for studying vascular bioeffects, highlighting its potential for drug delivery applications.

Cite This Study

Mühlenpfordt et al. (2025) studied this question.

synapsesocial.com/papers/68c1b34d54b1d3bfb60e9cc5https://doi.org/10.1016/j.ultrasmedbio.2025.07.007
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