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This is a In Vitro Study study.

September 10, 2025CureusOpen Access

Valproic Acid Causes Extensive Cell Detachment and Death in Differentiated Sh-SY5Y Cell Cultures: An In Vitro Observation

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In vitro observation reveals valproic acid induces significant cell detachment and death, suggesting teratogenic effects.

Valproic acid induces a 95.9% reduction in cell adherence at 10 mM concentration, highlighting its toxicity.
At 1 mM concentration, valproic acid leads to a 44.0% decrease in adherent differentiated SH-SY5Y cells.
The study analyzed morphological changes in treated versus untreated cells to assess the effects of valproic acid.
These findings suggest a critical need for further research on the teratogenic effects of valproic acid on neuronal cells.

Dardalas et al. (2025) studied this question.

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