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September 10, 2025Chemical CommunicationsOpen Access

PFOA induces fission of phase-separated phospholipid vesicles

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Authors

SHSeungsu HanUniversity of GenevaEPEmad PirhadiUniversity at Buffalo, State University of New YorkXYXin YongSouthwest Petroleum University

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Implication

Experimental analysis shows PFOA disrupts vesicle structure in model cellular membranes, indicating PFAS hazards.

Key Points

  • PFOA causes rapid fission of phase-separated vesicles along the boundary, raising concerns about its impact on cells.
  • The study found that PFOA markedly alters the spontaneous curvature of vesicles, initiating the fission process.
  • Using all-atom molecular dynamics simulations, the research details the molecular mechanism behind PFOA-induced vesicle fission.
  • These findings emphasize the potential harmful effects of PFAS exposure on cellular membranes, necessitating further investigation.

Cite This Study

Han et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81854b1d3bfb60ec191https://doi.org/10.1039/d5cc03353e
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