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September 10, 2025ACS OmegaOpen Access

Inhibition of Cardiac p38 Highlights the Role of the Phosphoproteome in Heart Failure Progression

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Authors

SSSogol SedighiJohns Hopkins UniversityTLTing LiuSun Yat-sen UniversityRORobert N. O’MeallyJohns Hopkins University

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Overview

Investigating p38-Mapk inhibition improves cardiac function in heart failure, suggesting new pathways for treatment.

Key Points

  • Inhibition of cardiac p38-Mapk significantly protects against cardiac dysfunction in heart failure.
  • Proteomic analysis shows that SB203580 preserved mitochondrial energetics and reduced oxidative stress.
  • Assessment through M-mode echocardiography demonstrated improved cardiac function with p38 inhibition.
  • Findings indicate that p38-Mapk inhibition influences critical pathways in cardiac remodeling and hypertrophy.

Cite This Study

Sedighi et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81f54b1d3bfb60ec672https://doi.org/10.1021/acsomega.5c03687
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