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September 10, 2025Journal of XenobioticsOpen Access

The Gut Microbiota Metabolite Urolithin B Mitigates Cholestatic Liver Injury in Mice via Modulating the Crosstalk Between PPARα, Nrf2, and NF-κB Signaling Pathways

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Authors

HAHani M. AlrawiliMEMahmoud ElshalMSMarwa S. Serrya

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Overview

This study finds that urolithin B improves cholestatic liver injury markers in mice, suggesting antioxidant and anti-inflammatory properties through nrf2 and nf-kb pathways.

Key Points

  • Urolithin B reduced liver injury markers in mice with cholestatic liver injury caused by ANIT.
  • The treatment with Urolithin B led to significant improvements in serum transaminases and bilirubin levels.
  • Urolithin B modulates the interactions between nrf2, nf-kb, and pparα signaling pathways, enhancing liver health.
  • Histopathological analyses showed Urolithin B's effectiveness in preserving hepatic architecture and reducing inflammation.

Cite This Study

Alrawili et al. (2025) studied this question.

synapsesocial.com/papers/68c1c62f54b1d3bfb60f1d36https://doi.org/10.3390/jox15040128
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Urolithin A’s Antioxidative, Anti-Inflammatory, and Antiapoptotic Activities Mitigate Doxorubicin-Induced Liver Injury in Wistar Rats2023 · 31 citations
  2. 2Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist2018 · 91 citations
  3. 3Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist2018 · 20 citations
  4. 4Urolithin C Ameliorates Hyperuricemia by Mitigating Renal Dysfunction through ROS-p38/ERK MAPK Axis Suppression2025 · 3 citations
  5. 5Urolithin A suppresses NLRP3 inflammasome activation by inhibiting the generation of reactive oxygen species and prevents monosodium urate crystal-induced peritonitis2024 · 7 citations