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September 10, 2025Frontiers in Cellular and Infection MicrobiologyOpen Access

Effects of oral gavage with periodontal pathogens and plaque biofilm on gut microbiota ecology and intestinal tissue architecture in mice: a mechanistic study

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Authors

LHLan HuangSGSong GeKYKun Yang

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Overview

Mechanistic analysis reveals how periodontal pathogens disrupt gut microbiota and contribute to inflammation.

Key Points

  • Oral gavage of periodontal pathogens led to significant intestinal barrier disruption, highlighting their systemic effects.
  • Gavage with P. gingivalis resulted in an increase in inflammatory markers IL-1β and TNF-α in colon tissues (P < 0.001).
  • Assessment utilized 16S rRNA sequencing and immunohistochemistry to analyze gut microbiota changes and tissue architecture.
  • Findings suggest periodontal pathogens may drive gut dysbiosis through immune modulation, exacerbating gastrointestinal issues.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68c1c63e54b1d3bfb60f267ahttps://doi.org/10.3389/fcimb.2025.1589055
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