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September 10, 2025Therapeutics and Clinical Risk ManagementOpen Access

Neoadjuvant Therapy for Organ Preservation in Locally Advanced Rectal Cancer: A Review

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Authors

QLQiuxia LiJLJianjun Li

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Overview

Review reveals neoadjuvant therapy enhances tumor regression in locally advanced rectal cancer, indicating potential for better quality of life.

Key Points

  • Neoadjuvant therapies lead to improved tumor regression, enhancing organ preservation outcomes in patients.
  • Emerging clinical data show that neoadjuvant approaches can achieve a complete response in locally advanced rectal cancer.
  • Chemoradiotherapy and total mesorectal excision are effective but can impair patient quality of life.
  • Consolidation neoadjuvant therapy and total neoadjuvant therapy may promote long-term cancer control in LARC patients.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc2354b1d3bfb60f3fe9https://doi.org/10.2147/tcrm.s518959
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