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September 10, 2025CancersOpen Access

Neoadjuvant Treatment for Locally Advanced Rectal Cancer: Current Status and Future Directions

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Authors

MIMasayoshi IwamotoKUKazuki UedaJKJunichiro Kawamura

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Overview

This narrative review examines neoadjuvant therapy and non-operative management for locally advanced rectal cancer, highlighting urgent issues and emerging strategies.

Key Points

  • Neoadjuvant therapy aims to improve outcomes for locally advanced rectal cancer patients.
  • Total neoadjuvant therapy integrates chemotherapy and radiotherapy, enhancing treatment options.
  • Molecular biomarkers and artificial intelligence could personalize treatment and prognostication.
  • Challenges such as optimal sequencing and treatment response evaluation need addressing.

Cite This Study

Iwamoto et al. (2025) studied this question.

synapsesocial.com/papers/68c1a76954b1d3bfb60e04c6https://doi.org/10.3390/cancers17152540
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advancing Personalized Medicine in the Treatment of Locally Advanced Rectal Cancer2024 · 3 citations
  2. 2The multidisciplinary management of locally advanced rectal cancer2024 · 1 citations
  3. 3Moving beyond anatomy: the future of rectal cancer management is biologically-informed, response-adapted, and patient-centered2026
  4. 4The Expansion of Curative Treatment Options for Locally Advanced Rectal Cancer as a Model for the Translation of Personalized Medicine2026
  5. 5Neoadjuvant Therapy for Organ Preservation in Locally Advanced Rectal Cancer: A Review2025