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March 19, 2026ONCOLOGIEOpen Access

From radical resection to organ preservation: the evolution of neoadjuvant therapies in rectal cancer

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Authors

MGMaria Chiara Lo GrecoGAGrazia AcquavivaRMRoberto Milazzotto

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Overview

Narrative review identifies new organ preservation strategies for rectal cancer, suggesting individualized treatment benefits.

Key Points

  • The aim is to explore how neoadjuvant therapies have evolved to support organ preservation in rectal cancer.
  • Provided a narrative overview of neoadjuvant approaches including radiotherapy and chemotherapy.
  • Analyzed literature and institutional data from a cohort of 65 patients using an organ preservation pathway.
  • Focused on the integration of imaging guidance and treatment individualization.
  • A clinical complete response was achieved in 30% of patients.
  • 34.5% of patients who underwent surgery achieved a pathological complete response.
  • 50% of patients with clinical complete response were managed without surgery.

Cite This Study

Greco et al. (2026) studied this question.

synapsesocial.com/papers/69bb92f2496e729e62980ae0https://doi.org/10.1515/oncologie-2025-0526
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Organ preservation in rectal cancer: an endoscopist’s perspective on current evidence and future directions2026 · 1 citations
  2. 2Organ preservation in early-stage rectal cancer: a narrative review of biological rationale, treatment strategies, and future directions2026
  3. 3Organ preservation in rectal cancer following clinical complete response after short-course radiotherapy-based total neoadjuvant therapy2026
  4. 4Organ preservation with total neoadjuvant therapy in early‐stage rectal cancer: A statewide analysis2026 · 1 citations
  5. 5Advancing Personalized Medicine in the Treatment of Locally Advanced Rectal Cancer2024 · 3 citations