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June 14, 2026Clinical and Translational Radiation OncologyOpen Access

Organ preservation in rectal cancer following clinical complete response after short-course radiotherapy-based total neoadjuvant therapy

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Authors

CMCarlos MoralesEMErik ManríquezVDValentina Duran

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Overview

Retrospective cohort evaluates organ preservation outcomes in rectal cancer after response-adapted therapy, highlighting implications for treatment.

Key Points

  • This research aims to assess the feasibility of organ preservation in rectal cancer patients achieving clinical complete response following short-course radiotherapy-based total neoadjuvant therapy.
  • Retrospective cohort of patients with stage II–III rectal cancer treated with short-course radiotherapy followed by chemotherapy.
  • Patients underwent tumor response assessment through digital rectal examination, pelvic MRI, flexible sigmoidoscopy, and CEA levels.
  • Those achieving clinical complete response were managed with a structured watch-and-wait protocol.
  • 19 of 51 patients (37.3%) achieved clinical complete response after treatment.
  • Among watch-and-wait patients, 3 (16.7%) experienced local regrowth, which was managed effectively with R0 resection.
  • The estimated 24-month local regrowth-free survival rate was 82.2% (95% CI 65.8–100%).

Cite This Study

Morales et al. (2026) studied this question.

synapsesocial.com/papers/6a2e44a3b1cc60ccdea8a332https://doi.org/10.1016/j.ctro.2026.101216
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