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September 10, 2025International Journal of PharmaceuticsOpen Access

3D-printed biomaterial-based scaffolds loaded with zoledronic acid functionalised ceramic microparticles for sustained release

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Authors

ADAikaterini DedeloudiLMLaura Martinez‐MarcosTQThomas Quinten

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Overview

This research develops 3D-printed scaffolds integrating zoledronic acid for targeted release in bone therapies, suggesting enhanced treatment safety.

Key Points

  • The developed scaffolds exhibited sustained release of zoledronic acid over two weeks, mitigating systemic side effects from treatment.
  • Assessment revealed that the 3D printing method ensured structural integrity, with HA-ZLD composites effectively integrated into the polymer matrix.
  • Thermal and mechanical analyses confirmed the composite's enhanced properties, highlighting the role of zoledronic acid in altering scaffold characteristics.
  • The fabrication process established shows promise for applications in targeted drug delivery systems for bone-related disorders.

Cite This Study

Dedeloudi et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc4754b1d3bfb60f4e3dhttps://doi.org/10.1016/j.ijpharm.2025.126101
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