What question did this study set out to answer?

To develop and evaluate 3D-printed hydroxyapatite bioceramic scaffolds reinforced with yttria-stabilized zirconia and coated with chitosan for load-bearing bone tissue regeneration.

August 15, 2026Rapid Prototyping Journal

Additive manufacturing of hydroxyapatite/3Y-ZrO2 bioceramics by digital light processing: enhanced mechanical strength, cytocompatibility, and antibacterial performance for potential load-bearing bone repair

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Authors

RDRuken Das BABülent Aktaş HAHatice Gumushan Aktas

Discussion

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Overview

In vitro material study demonstrates enhanced mechanical strength, cytocompatibility, and antibacterial efficacy in 3D-printed bioceramic scaffolds, highlighting potential for bone repair.

Key Points

To develop and evaluate 3D-printed hydroxyapatite bioceramic scaffolds reinforced with yttria-stabilized zirconia and coated with chitosan for load-bearing bone tissue regeneration.
Fabricated hydroxyapatite/3Y-ZrO2 scaffolds using digital light processing (DLP) additive manufacturing followed by sintering at optimized temperatures up to 1250 °C.
Characterized phase composition and microstructure using XRD and scanning electron microscopy, alongside compressive, flexural, and fracture toughness testing.
Assessed in vitro cytocompatibility using 14-day osteoblast viability assays and evaluated antibacterial performance of chitosan coatings against S. aureus and E. coli.
The optimized HZ-3 scaffold sintered at 1250 °C achieved a compressive strength of 285.36 MPa, flexural strength of 26.02 MPa, fracture toughness of 1.18 MPa·m½, and relative density of 93.9%.
Osteoblast viability reached up to 98.67% after 14 days of culture, confirming cytocompatibility across porous networks (>500 µm pores, >90% porosity).
Chitosan-functionalized surfaces reduced bacterial adhesion by 99.1% for Staphylococcus aureus and 90.7% for Escherichia coli.

Cite This Study

Das et al. (2026) studied this question.

synapsesocial.com/papers/6a8019bb75c2e31742c85db1 https://doi.org/10.1108/rpj-02-2026-0087

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August 15, 2026Rapid Prototyping Journal

Additive manufacturing of hydroxyapatite/3Y-ZrO2 bioceramics by digital light processing: enhanced mechanical strength, cytocompatibility, and antibacterial performance for potential load-bearing bone repair

View Full Paper

Ask AI

Bookmark

Authors

RDRuken Das BABülent Aktaş HAHatice Gumushan Aktas

Discussion

Member takes

Overview

In vitro material study demonstrates enhanced mechanical strength, cytocompatibility, and antibacterial efficacy in 3D-printed bioceramic scaffolds, highlighting potential for bone repair.

Key Points

To develop and evaluate 3D-printed hydroxyapatite bioceramic scaffolds reinforced with yttria-stabilized zirconia and coated with chitosan for load-bearing bone tissue regeneration.
Fabricated hydroxyapatite/3Y-ZrO2 scaffolds using digital light processing (DLP) additive manufacturing followed by sintering at optimized temperatures up to 1250 °C.
Characterized phase composition and microstructure using XRD and scanning electron microscopy, alongside compressive, flexural, and fracture toughness testing.
Assessed in vitro cytocompatibility using 14-day osteoblast viability assays and evaluated antibacterial performance of chitosan coatings against S. aureus and E. coli.
The optimized HZ-3 scaffold sintered at 1250 °C achieved a compressive strength of 285.36 MPa, flexural strength of 26.02 MPa, fracture toughness of 1.18 MPa·m½, and relative density of 93.9%.
Osteoblast viability reached up to 98.67% after 14 days of culture, confirming cytocompatibility across porous networks (>500 µm pores, >90% porosity).
Chitosan-functionalized surfaces reduced bacterial adhesion by 99.1% for Staphylococcus aureus and 90.7% for Escherichia coli.

Cite This Study

Das et al. (2026) studied this question.

synapsesocial.com/papers/6a8019bb75c2e31742c85db1 https://doi.org/10.1108/rpj-02-2026-0087

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