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September 10, 2025Discover OncologyOpen Access

The causal relationship between inflammatory cytokines and lung cancer: a two-sample bidirectional mendelian randomization study

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Authors

KZKaiyang ZhaoNWNing WangPHPing-qing He

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Overview

Bidirectional mendelian randomization uncovers associations between inflammatory cytokines and lung cancer, suggesting potential pathways for treatment.

Key Points

  • Three inflammatory cytokines were identified with a causal relationship to lung cancer.
  • CCL25 increases lung cancer risk, while GDNF and IL-18 offer protective factors, suggesting complexity in cytokine roles.
  • Utilizing mendelian randomization, the study confirmed findings across multiple statistical methods to ensure robustness.
  • The research enhances understanding of cytokines in lung cancer, potentially guiding future prevention and treatment strategies.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68c1d01a54b1d3bfb60f62c2https://doi.org/10.1007/s12672-025-03256-x
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Also Consider

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  1. 1Causal association of circulating cytokines with the risk of lung cancer: a Mendelian randomization study2024 · 5 citations
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  4. 4Exploring the causal association between inflammatory cytokines and pancreatic cancer: a two-sample Mendelian randomized study2024
  5. 5Circulating levels of interleukins and lung cancer and its subtypes: A Mendelian randomization study2024