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September 10, 2025Annals of HematologyOpen Access

Outcomes of primary CNS lymphoma treated with combined immunochemotherapy with whole-brain radiotherapy

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Authors

YTYa Hwee TanSingHealth Duke-NUS Academic Medical CentreRLRyan Mao Heng LimNational Cancer Centre SingaporeJTJing Yuan TanSun Yat-sen University

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Implication

Retrospective study reports improved survival in PCNSL with HD-MTX and whole-brain radiotherapy, highlighting prognostic factors.

Key Points

  • Combined HD-MTX-based treatment methods significantly improved progression-free survival (PFS) and overall survival (OS) in PCNSL patients.
  • Multivariate analysis showed the Shah protocol led to better survival rates compared to the DeAngelis protocol, particularly in older patients.
  • Men and those with non-germinal center subtypes were at higher risk of poorer outcomes, indicating key prognostic factors in PCNSL.
  • Gene expression profiling suggested potential targets for immunotherapy, emphasizing the need for continued research in PCNSL treatment options.

Cite This Study

Tan et al. (2025) studied this question.

synapsesocial.com/papers/68c1d03e54b1d3bfb60f707bhttps://doi.org/10.1007/s00277-025-06561-1
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