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September 10, 2025TrialsOpen Access

Protocol for a randomized controlled trial of a resistance exercise training to treat major depression via cerebrovascular mechanisms (RESIST Trial)

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Authors

JMJacob D. Meyer SSSeana L. Smith JGJohn M. Gidley

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Overview

Randomized controlled trial tests resistance exercise training effects on depressive symptoms and cerebral blood flow in adults, suggesting new treatment possibilities.

Key Points

Resistance exercise training may improve symptoms in major depressive disorder, supporting its potential as a treatment.
Primary outcomes include depressive symptom severity assessed using standardized rating scales at multiple time points.
The trial involves 200 adults with DSM-5-diagnosed major depressive disorder, comparing high-dose versus low-dose training effects.
If confirmed effective, resistance exercise training could provide a low-cost and accessible alternative treatment for major depression.

Cite This Study

Meyer et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5ef54b1d3bfb60f8da2 https://doi.org/10.1186/s13063-025-09025-z

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September 10, 2025TrialsOpen Access

Protocol for a randomized controlled trial of a resistance exercise training to treat major depression via cerebrovascular mechanisms (RESIST Trial)

View Full Paper

Ask AI

Bookmark

Authors

JMJacob D. Meyer SSSeana L. Smith JGJohn M. Gidley

Discussion

Member takes

Overview

Randomized controlled trial tests resistance exercise training effects on depressive symptoms and cerebral blood flow in adults, suggesting new treatment possibilities.

Key Points

Resistance exercise training may improve symptoms in major depressive disorder, supporting its potential as a treatment.
Primary outcomes include depressive symptom severity assessed using standardized rating scales at multiple time points.
The trial involves 200 adults with DSM-5-diagnosed major depressive disorder, comparing high-dose versus low-dose training effects.
If confirmed effective, resistance exercise training could provide a low-cost and accessible alternative treatment for major depression.

Cite This Study

Meyer et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5ef54b1d3bfb60f8da2 https://doi.org/10.1186/s13063-025-09025-z

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