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December 18, 2024TrialsOpen Access

Treatment with combined exercise in patients with resistant major depression (TRACE-RMD): study protocol for a randomised controlled trial

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Why the study?

Exercise has a low-to-moderate effect on major depressive disorder, but evidence regarding exercise interventions in resistant major depression is lacking.

Does a 12-week supervised combined exercise program improve depressive symptoms in adults with resistant major depression?

Population

70 adults (≥ 18 years old) with resistant major depression

Comparison

12-week supervised combined exercise program vs treatment-as-usual

Design

Randomised, single-blind, controlled experimental trial

Follow-up

Three-month intervention period

Authors

NINagore Iriarte‐YollerUniversidad de DeustoJEJosé Etxaniz‐OsesUniversity of the Basque CountryCPCristóbal Pavón-NavajasUniversidad de Deusto

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Overview

This study protocol outlines a randomized controlled trial to evaluate whether a 12-week supervised combined exercise program improves depressive symptoms in adults with resistant major depression.

Structured PICO

Does a 12-week supervised combined exercise program improve depressive symptoms in adults with resistant major depression?

P
Population
70 adults (≥ 18 years old) with resistant major depression (RMD)
I
Intervention
12-week supervised combined (aerobic and resistance training) exercise program
C
Comparator
Treatment-as-usual (TAU)
O
Outcome
Depressive symptoms measured with the Montgomery-Asberg Depression Rating Scale after a three-month intervention periodpatient reported

This study protocol outlines a randomized controlled trial to evaluate whether a 12-week supervised combined exercise program improves depressive symptoms in adults with resistant major depression.

Cite This Study

Iriarte‐Yoller et al. (2024) studied this question.

synapsesocial.com/papers/6a08e497aa03afa536e4af67https://doi.org/10.1186/s13063-024-08685-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of combined exercise training for adults with resistant major depression: a pilot study from the TRACE-RMD project2025
  2. 2Protocol for a randomized controlled trial of a resistance exercise training to treat major depression via cerebrovascular mechanisms (RESIST Trial)2025
  3. 3Lived Experiences and Engagement in an Exercise Program for People with Resistant Major Depression: TRACE-RMD Study2026
  4. 4Study protocol: exercise training for treating major depressive disorder in multiple sclerosis2024 · 3 citations
  5. 5Efficacy and mechanisms of device-monitored aerobic exercise for depression treatment and cognitive function improvement (DAECD trail): protocol for a randomized controlled trial2026