Assessment of C-Reactive Protein, Presepsin and Lipopolysaccharide-Binding Protein Levels in Cardiac Surgery Patients With Postoperative Infectious-Inflammatory Complications

Introduction Postoperative infectious and inflammatory complications worsen the prognosis of patients, increase the duration of hospitalization and increase the cost of treatment, therefore, the search for markers to determine the degree of risk of their development is an urgent problem. The prognostic differentiating biomarkers presumably include presepsin and lipolysaccharide-binding protein, the dynamics of which in serum correlates with the severity of the infectious and inflammatory reaction. The aim: to conduct a pilot study to assess the dynamics of C-reactive protein, presepsin and lipolysaccharide-binding protein before surgery and on days 1 and 3 after cardiac surgery. Material and methods: the study was conducted on blood serum samples of male patients of the cardiac surgery department (n=27) with and without developed infectious inflammatory complications. Results: a significant increase in C-reactive protein was revealed on day 3 in all patients after cardiac surgery, while the further dynamics of C-reactive protein in patients with infectious complications differed from that in patients with a successful course of the postoperative period. In patients who did not have infectious and inflammatory complications, presepsin levels significantly increased compared to the baseline level on the first day after surgery, unlike patients who had complications. The value of the lipopolysaccharide-binding protein did not significantly differ between the groups. Conclusion: C-reactive protein and presepsin can be regarded as significant diagnostic markers of inflammation, their dynamics may indicate the development of a postoperative infectious and inflammatory complication. The lipolysaccharide-binding protein does not exhibit biomarker properties in this aspect due to a significant individual variation.