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September 10, 2025Nucleic Acids ResearchOpen Access

G-quadruplex-dependent transcriptional regulation by molecular condensation in the Bcl3 promoter

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Genomic analysis reveals G-quadruplex-dependent SP1 binding enhances transcriptional regulation in Bcl3.

G-quadruplexes play a crucial role in regulating transcription through SP1 binding in the Bcl3 promoter.
SP1 was found to be significantly enriched in the oncogenic Bcl3 promoter containing G4-forming sequences.
Formation of transcriptional condensates is essential for the activation of the Bcl3 promoter by G4-dependent SP1.
The presence of RNA and G4 formation notably influences the dissociation of SP1 condensates, highlighting their dynamics.

Yoo et al. (2025) studied this question.

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