Synthesis And Characterization Of New 1,2,3-Triazole Fused Phenol Based Glucose Triazole For Biological Evaluation

The synthesis and characterization of novel 1,2,3-triazole fused phenol-based glucose triazole derivatives have garnered significant interest due to their potential biological applications and unique structural properties. In this study, a series of glucose-triazole hybrids were synthesized via copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), a cornerstone reaction in click chemistry known for its efficiency, regioselectivity, and biocompatibility. The synthetic route involved the modification of glucose to introduce an azide moiety, followed by its reaction with phenol-derived alkynes to yield 1,4-disubstituted triazole derivatives under mild conditions. The synthesized compounds were thoroughly characterized using spectroscopic techniques, including ¹H NMR, FTIR, and mass spectrometry, confirming the successful formation of the triazole ring and the retention of key structural features. Biological evaluations, demonstrated promising results, highlighting the potential therapeutic applications of these glucose-triazole derivatives. The findings suggest that these triazole-fused glucose hybrids could serve as valuable scaffolds in the design and development of novel bioactive molecules with enhanced pharmacological profiles.