Three uremic patient groups were studied 50 on regular hemodialysis, 25 patients on Intermittent peritoneal dialysis and 25 patients on conservative management were evaluated for the presence of autonomic nervous system function impairment The uremic group were compared with a control group comprising 50 healthy individuals to four standardized cardiovascular autonomic reflex tests. The cardiovascular autonomic reflex tests consist of two types of tests. Those determine sympathetic functions by measuring changes in blood pressure in response to standing and sustained isometric exercise. Those determined parasympathetic functions by assessing variations in heart rate response during deep breathing and Valsalvamaneuver. It was found the frequency of both sympathetic and parasympathetic dysfunctions were significantly higher in the three uremic group than in the control group (34% versus 4%). {P-Value <0.005). The prevalence of sympathetic dysfunction according to the standardized sympathetic cardiovascular autonomic reflex test was 11% in the hemodialysis treated group, 30% in patients on intermittent peritoneal dialysis group and 40% in the non-replacement therapy group whereas the parasympathetic cardiovascular autonomic reflex test revealed parasympathetic dysfunctions in 21%, 56%, 60% of patients on hemodialysis, patients on intermittent peritoneal dialysis and patients on non-replacement therapy, respectively. Objective cardiovascular autonomic impairments are widely spread among patients with chronic renal failure in Mosul provenance with parasympathetic function impairment being more common than sympathetic function {p-value<0.005).
Theyab et al. (Thu,) studied this question.