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September 11, 2025

Sarcopenia-A Valuable Imaging Biomarker for Disease Progression in Patients With Primary Sclerosing Cholangitis (PSC)?

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Authors

ALAlena LeversJPJudith PantkeFKFilip Klimeš

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Overview

Observational analysis found that sarcopenia predicts liver-related event-free survival in PSC patients, indicating its prognostic value.

Key Points

  • Sarcopenia prevalence reached 27.7% in PSC patients, highlighting a significant public health concern.
  • A strong negative correlation exists between muscle mass and MELD score (r = -0.244), suggesting worse outcomes.
  • Data was collected from 224 PSC patients using magnetic resonance imaging to measure muscle mass accurately.
  • The presence of sarcopenia has implications for liver-related event-free survival, emphasizing its importance in clinical management.

Cite This Study

Levers et al. (2025) studied this question.

synapsesocial.com/papers/68c2a9c304ab598fffb89ad2https://doi.org/10.1111/liv.70328
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevalence and effect on prognosis of sarcopenia in patients with primary biliary cholangitis2024 · 12 citations
  2. 2A230 SARCOPENIA IN PRIMARY SCLEROSING CHOLANGITIS AND INFLAMMATORY BOWEL DISEASE IN PAEDIATRICS AND CLINICAL IMPLICATIONS2024
  3. 3Short, not skinny: The distinct sarcopenia phenotype of pediatric primary sclerosing cholangitis‐inflammatory bowel disease2026
  4. 4Imaging-based diagnosis of sarcopenia for transplant-free survival in primary sclerosing cholangitis2024 · 3 citations
  5. 5High Prevalence of Sarcopenia in Noncirrhotic Women With Primary Biliary Cholangitis: A Comparative Study of Clinical Characteristics and Risk Factors2026