September 16, 2025

Serotonin 5-HT

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Authors

EBEmma M. Bonniwell RARana Alabdali JHJoseph J. Hennessey

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Overview

Observational analysis reveals diverse signaling profiles and G protein interactions in serotonergic systems, suggesting implications for drug development.

Key Points

The study confirms the engagement of Gq/11 and alternative pathways by serotonin 5-HT2C receptors, establishing a basis for future therapeutic strategies.
Profiling of psychedelics like LSD shows a pronounced Gq/11 bias, indicating potential mechanisms behind their therapeutic effects in depression.
Increased RNA editing of the 5-HT2C receptor reduces signaling across multiple pathways, particularly G12/13, while preserving β-arrestin recruitment.
Insights into the promiscuity of 5-HT2C signaling may clarify the limitations of lorcaserin and guide future drug development efforts.

Cite This Study

Bonniwell et al. (2025) studied this question.

synapsesocial.com/papers/68c93fe601120bef803bb025 https://doi.org/10.1021/acschemneuro.5c00647

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September 16, 2025

Serotonin 5-HT

View Full Paper

Ask AI

Bookmark

Authors

EBEmma M. Bonniwell RARana Alabdali JHJoseph J. Hennessey

Discussion

Member takes

Overview

Observational analysis reveals diverse signaling profiles and G protein interactions in serotonergic systems, suggesting implications for drug development.

Key Points

The study confirms the engagement of Gq/11 and alternative pathways by serotonin 5-HT2C receptors, establishing a basis for future therapeutic strategies.
Profiling of psychedelics like LSD shows a pronounced Gq/11 bias, indicating potential mechanisms behind their therapeutic effects in depression.
Increased RNA editing of the 5-HT2C receptor reduces signaling across multiple pathways, particularly G12/13, while preserving β-arrestin recruitment.
Insights into the promiscuity of 5-HT2C signaling may clarify the limitations of lorcaserin and guide future drug development efforts.

Cite This Study

Bonniwell et al. (2025) studied this question.

synapsesocial.com/papers/68c93fe601120bef803bb025 https://doi.org/10.1021/acschemneuro.5c00647

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