What type of study is this?

This is a Systematic Review study (also classified as: Cohort Study).

September 20, 2025Nature MetabolismOpen Access

Mapping the plasma metabolome to human health and disease in 274,241 adults

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The study reveals over 52,000 metabolite-disease and trait associations, enhancing understanding of health.
Main findings indicate that cholesterol-related metabolites associate with the highest number of diseases, with 526 connections noted.
Utilizing machine learning, a metabolic risk score identified top metabolites as disease biomarkers, achieving over 0.8 in AUC performance.
Mendelian randomization supports causal links for 454 metabolite-disease pairs, suggesting shared genetic factors between them.

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A comprehensive atlas links plasma metabolites to 1,386 diseases, suggesting utility in precision medicine.

You et al. (2025) studied this question.

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