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March 6, 2024NatureOpen Access

Genome-wide characterization of circulating metabolic biomarkers

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Authors

MKMinna K. KarjalainenSKSavita KarthikeyanCOClare Oliver‐Williams

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Overview

Genome-wide association study reveals over 400 loci for 233 metabolic traits in 136,016 individuals, highlighting genetic drivers of systemic metabolism across diverse diseases.

Key Points

  • Extensive metabolomics profiling reveals over 400 independent genetic loci linked to circulating traits, with candidate causal genes assigned across two-thirds of regions.
  • Genome-wide association study across 136,016 individuals quantified 233 metabolic traits using nuclear magnetic resonance spectroscopy, uncovering granular lipid variants.
  • Mendelian randomization analysis demonstrates significant genetic pleiotropy across metabolic pathways, supporting a putative causal role for circulating acetone in hypertension.

Cite This Study

Karjalainen et al. (2024) studied this question.

synapsesocial.com/papers/68e75683b6db6435876ce2echttps://doi.org/10.1038/s41586-024-07148-y
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