Why the study?
Detailed knowledge of the genetic determinants of systemic metabolism is pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases.
Population
Up to 136,016 participants from 33 predominantly population-based cohorts
Design
Genome-wide association study meta-analysis
Key result
A genome-wide association meta-analysis of 233 circulating metabolic traits in up to 136,016 participants identified over 400 independent loci, revealing substantial pleiotropy and novel pathways.
Authors
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Extends the genetic map of 233 metabolites in large cohorts; leaves open causal links to cardiovascular disease.
Meta-Analysis (n=136,016)
Yes
p-value: p=< 5 × 10-8
This large-scale genome-wide association study of 233 circulating metabolic traits identified over 400 independent loci, revealing substantial genetic pleiotropy and novel pathways linking metabolism to complex diseases.
Karjalainen et al. (2022) conducted a meta-analysis in Circulating metabolic traits (n=136,016). Genetic variants (SNPs) vs. Reference alleles was evaluated on Genome-wide significant associations with 233 metabolic traits (p=< 5 × 10-8). A genome-wide association meta-analysis of 233 circulating metabolic traits in up to 136,016 participants identified over 400 independent loci, revealing substantial pleiotropy and novel pathways.
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