Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 22, 2026NatureOpen Access

Genetic analysis of circulating metabolic traits in 619,372 individuals

View Full Paper
Ask AI
Bookmark
Share

Authors

RTRalf TambetsUniversity of TartuMJMihkel JesseUniversity of TartuJKJaanika KronbergUniversity of Tartu

Discussion

Loading...

Member takes

Implication

Randomized trial identifies genetic links to metabolic traits in diverse populations, suggesting implications for disease risk assessment.

Key Points

  • The aim is to improve the understanding of genetic variants associated with circulating metabolic traits.
  • Performed a GWAS meta-analysis for 249 traits in the Estonian Biobank and UK Biobank with 619,372 individuals.
  • Identified 88,127 locus-trait associations and employed statistical fine mapping and colocalization analyses.
  • Explored causal relationships between metabolic traits and disease outcomes using cis-Mendelian randomization.
  • Identified 88,127 common and low-frequency associations across 8,398 loci.
  • Predicted links between plasma BCAAs and type 2 diabetes risk, suggesting lower BCAA levels may not reduce disease risk.
  • Found that 19.4% of fine-mapped variants had low minor allele frequencies, enriched for missense and splice-altering mutations.

Cite This Study

Tambets et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff362d674f7c03778bfd9https://doi.org/10.1038/s41586-026-10532-5
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genome-wide characterization of circulating metabolic biomarkers2024 · 269 citations
  2. 2Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program2024 · 426 citations
  3. 3Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease2022 · 433 citations
  4. 4<scp>UCSF ChimeraX</scp>: Tools for structure building and analysis2023 · 4,781 citations
  5. 5Efficient "pythonic" access to FASTA files using pyfaidx2015 · 66 citations