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September 12, 2025PharmaceuticsOpen Access

Invasomes and Nanostructured Lipid Carriers for Targeted Delivery of Ceftazidime Combined with N-Acetylcysteine: A Novel Approach to Treat Pseudomonas aeruginosa-Induced Keratitis

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Authors

MJMina JosefMAMenna M. AbdellatifRARehab Abdelmonem

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Overview

Optimized ceftazidime-loaded invasomes and nanostructured lipid carriers enhance antimicrobial activity, suggesting improved healing in keratitis.

Key Points

  • The optimized CTZ-loaded INV formula demonstrated superior corneal permeation, enhancing treatment effectiveness.
  • CTZ-loaded NLC showed a higher entrapment efficiency and a sustained drug release profile, indicating effective formulation.
  • Combining NAC with CTZ-loaded nanocarriers yielded enhanced antibacterial activity and biofilm inhibition against Pseudomonas aeruginosa.
  • In vivo results confirmed that the CTZ-loaded INV formula with NAC rapidly eradicates keratitis, indicating promising therapeutic potential.

Cite This Study

Josef et al. (2025) studied this question.

synapsesocial.com/papers/68d44a3731b076d99fa53711https://doi.org/10.3390/pharmaceutics17091184
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Also Consider

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  5. 5Facile Fabrication of Multifunctional Metal-Phenolic Network Nanoparticles for Bacterial Keratitis Treatment2026 · 1 citations