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September 12, 2025AgingOpen Access

Roles of plasminogen activator inhibitor-1 in aging-related muscle and bone loss in mice

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Authors

TOTakashi OhiraNKNaoyuki KawaoYMYuya Mizukami

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Overview

Analysis reveals PAI-1 deficiency reduces muscle and bone loss in aging mice, indicating its impact on sarcopenia and osteoporosis.

Key Points

  • PAI-1 deficiency significantly blunted aging-related muscle mass and grip strength declines in female mice, indicating its critical role.
  • Compared to 6-month-old mice, 24-month-old mice exhibited clear deficits in both muscle and bone parameters, highlighting age impact.
  • Investigation involved gene-deficient and wild-type mice to assess PAI-1's involvement in aging-related disorders over time.
  • Findings suggest PAI-1 contributes to sarcopenia and osteopenia in aging females, but the underlying mechanisms need further exploration.

Cite This Study

Ohira et al. (2025) studied this question.

synapsesocial.com/papers/68d44a4031b076d99fa537a1https://doi.org/10.18632/aging.206318
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