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October 9, 2025Circulation Research

Abstract Fri020: Plasminogen Activator Inhibitor-1 Governs Vascular Aging

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Authors

AKAlireza KhoddammohammadiAKAnthony KalousdianMEMesut Eren

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Overview

Genetic reduction of PAI-1 improves cardiovascular function in aging mice, suggesting new therapeutic avenues.

Key Points

  • Genetic reduction of PAI-1 was linked to a 20% increase in overall survival in mice.
  • PAI-1 overexpression resulted in heightened cardiovascular pathophysiology, worsening outcomes in aging.
  • Using L-NAME treatment, researchers assessed changes in blood pressure and vascular stiffness in models.
  • Pharmacological inhibition of PAI-1 reversed age-related increases in aortic pulse wave velocity.

Cite This Study

Khoddammohammadi et al. (2025) studied this question.

synapsesocial.com/papers/68e80eb363e2e2f707877d5fhttps://doi.org/10.1161/res.137.suppl_1.fri020
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasminogen Activator Inhibitor-1 promotes aortic aging-like pathophysiology in humans and mice2025
  2. 2Plasminogen Activator Inhibitor-1 Antagonist TM5441 Attenuates N <sup>ω</sup> -Nitro- <scp>l</scp> -Arginine Methyl Ester–Induced Hypertension and Vascular Senescence2013 · 133 citations
  3. 3Plasminogen Activator Inhibitor-1 Deficiency Prevents Hypertension and Vascular Fibrosis in Response to Long-term Nitric Oxide Synthase Inhibition2001 · 163 citations
  4. 4Plasminogen Activator Inhibitor-1 as a Therapeutic Target for Healthy Longevity, Immunosenescence, and Age-Related Disease: Translational Development of the Small-Molecule Inhibitor TM56142026 · 1 citations
  5. 5Pharmacological Inhibition and Genetic Deficiency of Plasminogen Activator Inhibitor-1 Attenuates Angiotensin II/Salt-Induced Aortic Remodeling2004 · 109 citations