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September 12, 2025European Respiratory JournalOpen Access

Ultrasonic Elastography-guided Pleural Biopsy versus Traditional Thoracic Ultrasound-guided Pleural Biopsy for the Diagnosis of Pleural Effusion: A Multicentre Randomized Trial

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Ultrasonic elastography-guided pleural biopsy significantly increased sensitivity for diagnosing malignant pleural effusion compared to traditional methods.
The sensitivity for detecting malignant pleural effusion was 85% in the ultrasonic elastography group, compared to 63% in the traditional group.
A multicentre, randomized trial enrolled 232 patients with pleural effusion, comparing the two biopsy methods to assess diagnostic rates and safety.
Ultrasonic elastography provided better diagnostic yield with similar safety to traditional methods, supporting its use in clinical practice.

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Randomized trial finds ultrasonic elastography superior for diagnosing malignant pleural effusion, suggesting better outcomes.

Deng et al. (2025) studied this question.

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