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September 12, 2025MOLECULAR SCIENCES AND APPLICATIONSOpen Access

The Protective Effect of Isosorbide Dinitrate or L-arginine on Acute Ethanol-induced Oxidative Stress and Histopathological Changes in Different Organs

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Authors

OAOmar M. E. Abdel‐SalamNational Research Centre EYEman R. YounessCairo University FMFatma A. MorsyCairo University

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Implication

This study examines how isosorbide dinitrate and l-arginine mitigate oxidative stress and histopathological changes in animal models, suggesting potential therapeutic roles.

Key Points

Ethanol treatment significantly elevated malondialdehyde and nitric oxide levels in the brain and liver.
Treatment with isosorbide dinitrate or l-arginine significantly reduced oxidative stress biomarkers dose-dependently.
Both treatments improved reduced glutathione levels and paraoxonase-1 activities compared to ethanol control.
Histological analysis revealed protective effects of isosorbide dinitrate and l-arginine against organ damage.

Cite This Study

Abdel‐Salam et al. (2025) studied this question.

synapsesocial.com/papers/68d44b2231b076d99fa54041 https://doi.org/10.37394/232023.2025.5.7

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Implication

This study examines how isosorbide dinitrate and l-arginine mitigate oxidative stress and histopathological changes in animal models, suggesting potential therapeutic roles.

The Protective Effect of Isosorbide Dinitrate or L-arginine on Acute Ethanol-induced Oxidative Stress and Histopathological Changes in Different Organs

Discussion

Member takes

Implication

Key Points

Cite This Study

The Protective Effect of Isosorbide Dinitrate or L-arginine on Acute Ethanol-induced Oxidative Stress and Histopathological Changes in Different Organs

Discussion

Member takes

Implication

Key Points

Cite This Study

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