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August 1, 1994Alcoholism Clinical and Experimental Research

Effects of Nitric Oxide‐Related Agents on Alcohol Narcosis

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Key result

Pretreatment with the NOS inhibitor NAME (30-100 mg/kg) increased the duration of alcohol-induced loss of righting reflex, whereas the NO donor ISDN (30 mg/kg) decreased LORR duration in rats.

Why the study?

Does modulation of nitric oxide affect alcohol narcosis in adult male rats?

Population

Adult male rats

Comparison

Pretreatment with a NO synthase inhibitor, a NOS… vs Alcohol alone or different combinations of the…

Design

Preclinical

Authors

MAMichael L. AdamsCampden BRI (Hungary)EMEdward R. MeyerNational Audubon SocietyBSBryan N. SewingWashington University in St. Louis

Discussion

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Implication

Supports NO mediation of alcohol sedation in rats; leaves open human translation and clinical relevance.

Structured PICO

Does modulation of nitric oxide affect alcohol narcosis in adult male rats?

P
Population
Adult male rats
I
Intervention
Pretreatment with a NO synthase (NOS) inhibitor (NG-nitro-l-arginine methyl ester [NAME]), a NOS substrate (l-arginine methyl ester [AME]), or a NO donor (isosorbide dinitrate [ISDN]), followed by anesthetic doses (3-5 g/kg, ip) of alcohol
C
Comparator
Alcohol alone or different combinations of the agents
O
Outcome
Onset and duration of alcohol-induced loss of the righting reflex (LORR)surrogate

Inhibition of nitric oxide synthase enhances alcohol-induced narcosis, while nitric oxide donors inhibit it, suggesting NO pathways mediate part of alcohol's sedative-hypnotic effects.

Cite This Study

Adams et al. (1994) studied Alcohol narcosis. Nitric oxide-related agents (NAME, AME, ISDN) and alcohol was evaluated on Onset and duration of alcohol-induced loss of the righting reflex (LORR). Pretreatment with the NOS inhibitor NAME (30-100 mg/kg) increased the duration of alcohol-induced loss of righting reflex, whereas the NO donor ISDN (30 mg/kg) decreased LORR duration in rats.

synapsesocial.com/papers/6a157565814bf8ec9a4e9ea9https://doi.org/10.1111/j.1530-0277.1994.tb00068.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  3. 3Nitric oxide does not modulate whole body oxygen consumption in anesthetized dogs1999 · 24 citations
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