June 2, 2010Alcohol and Alcoholism

Vascular Actions of Nitric Oxide as Affected by Exposure to Alcohol

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Why the study?

Does exposure to alcohol affect the vascular actions of nitric oxide in healthy individuals and experimental models?

Population

Healthy individuals, human materials and various experimental animals

Design

Review

Authors

NTNoboru TodaNational Institute of Advanced Industrial Science and Technology KAKazuhide AyajikiHyogo University of Health Sciences

Discussion

Member takes

Implication

May explain alcohol's J-shaped CV risk; hypothesis-generating and should not yet change practice.

Structured PICO

Does exposure to alcohol affect the vascular actions of nitric oxide in healthy individuals and experimental models?

Population

Healthy individuals, human materials and various experimental animals

Intervention

Exposure to alcohol (low and high concentrations, chronic ingestion) and acetaldehyde

Outcome

Vascular actions of NO derived from endothelial and neuronal NOSsurrogate

Alcohol exerts a dose-dependent, biphasic effect on vascular nitric oxide bioavailability, which may explain its complex cardiovascular effects.

Cite This Study

Toda et al. (2010) studied this question.

synapsesocial.com/papers/6a6ff3ee8031ec7bb1dc06c2 https://doi.org/10.1093/alcalc/agq028

Topics

Hypertension management

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Vascular Actions of Nitric Oxide as Affected by Exposure to Alcohol

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Vascular Actions of Nitric Oxide as Affected by Exposure to Alcohol

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider