Correlation between Serum Bilirubin and Lipid Profile in Acute Myocardial Infarction

Background: Acute Myocardial Infarction (AMI) is a leading cause of morbidity and mortality worldwide. Oxidative stress plays a critical role in AMI pathogenesis. Bilirubin, an endogenous antioxidant, may influence cardiovascular risk by interacting with lipid metabolism. Objective: To investigate the correlation between serum bilirubin levels and lipid profile parameters in patients with AMI. Methods: A cross-sectional study was conducted on 300 patients diagnosed with AMI. Serum bilirubin (total, direct, indirect) and lipid profile parameters, total cholesterol, LDL, HDL, were measured. Statistical analysis was performed using Pearson’s correlation coefficient to determine associations. Results: Mean serum bilirubin levels were 0.93 ± 1.33 mg/dL. Serum total bilirubin showed a negative correlation with total cholesterol (r = –0.145 p < 0.05) and LDL cholesterol (r = –0.154, p < 0.05), while a positive correlation was observed with HDL cholesterol (r = +0.36, p < 0.05). Conclusion: Elevated bilirubin levels may be protective in AMI by modulating lipid profiles, suggesting a potential role in cardiovascular risk stratification.