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September 12, 2025Open Access

Synergistic Chemo-Photothermal Therapy Using Doxorubicin-Loaded Gold Nanorods for Enhanced Apoptosis in Lung Cancer Cells

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Authors

GRGhazalsadat Mousavi RamhormoziSKSaeid Reza KhatamiHGHamid Galehdari

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Overview

This analysis shows enhanced apoptosis with combined doxorubicin and gold nanorods in lung cancer, suggesting that photothermal therapy effectively improves outcomes.

Key Points

  • The combination of doxorubicin and gold nanorods significantly enhances apoptosis in lung cancer cells.
  • Results show a 60% increase in apoptosis with a low concentration of doxorubicin (0.078 µM) below its IC50 level.
  • The introduction of NIR laser irradiation improves doxorubicin delivery and increases membrane permeability.
  • The therapy activates both intrinsic and extrinsic apoptotic pathways, indicating a robust therapeutic strategy.

Cite This Study

Ramhormozi et al. (2025) studied this question.

synapsesocial.com/papers/68d44c3d31b076d99fa55928https://doi.org/10.21203/rs.3.rs-7437340/v1
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